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Influence of pentoxifylline, A-802710, propentofylline and A-802715 Hoechst on the expression of cell cycle blocks and S-phase content after irradiation damage




, : Influence of pentoxifylline, A-802710, propentofylline and A-802715 Hoechst on the expression of cell cycle blocks and S-phase content after irradiation damage. Biochimica et Biophysica Acta 1499(1-2): 1-10

The toxicity of the five methylxanthine derivatives, caffeine, pentoxifylline, A802710, propentofylline and A802715, was determined against the two human melanoma lines, Bell and MeWo, and against the two human squamous cell carcinoma lines, 4197 and 4451, by vital staining assay. Pentoxifylline and A802710 emerge as the least toxic showing TD50 (toxic dose of 50%) levels of 3.0-4.0 mM. Propentofylline and caffeine take an intermediate position. A802715 has a TD50 of 0.9-1.1 mM and is the mos...

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