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Efeito da dexametasona e do cetoprofeno na osteogenese e na resistencia ossea em ratosossea em ratos


, : Efeito da dexametasona e do cetoprofeno na osteogenese e na resistencia ossea em ratosossea em ratos.

O presente estudo teve como objetivo avaliar o efeito do cetoprofeno e da dexametasona na osteog nese ao redor de implante de hidroxiapatita densa (HAD) na t bia, no osso parietal, e na resist ncia ssea. Utilizaram-se 15 ratos Wistar, pesando 250 30 g, com 50 dias de idade. Ap s a anestesia com quetamina/xilazina IM, produziu-se no osso parietal e na ep fise proximal da t bia uma cavidade de 3 mm, sendo implantada a HAD. Ap s a cirurgia os animais foram divididos em tr s grupos (n=5): controle (CT), anti-inflamat rio n o esteroidal (AINES) e anti-inflamat rio esteroidal (AIES). O grupo AINES foi submetido ao tratamento com cetoprofeno na dose de 12 mg/Kg/dia, o AIES recebeu doses de 0,10 mg/kg/dia de dexametasona o grupo CT recebeu solu o fisiol gica 0,9% (SF) por via subcut nea durante 30 dias. Todos os grupos receberam a mesma dieta s lida e gua ad libitum. Ap s 30 dias de experimento os animais sofreram eutan sia, os f mures coletados, para teste mec nico, e os locais do implante das t bias e o osso parietal, para an lise histomorfom trica. Os grupos AINES e AIES apresentaram menor volume de osso neoformado na falha ssea e ao redor do implante de HAD , como tamb m, menor for a m xima para a ruptura completa dos f mures, quando comparados com o grupo CT. O uso do cetoprofeno e a dexametasona interferiram na osteog nese ao redor do implante de HAD e no osso parietal, diminuindo a resist ncia ssea principalmente pela inibi o da COX2 e diminui o das prostaglandinas, comprometendo a estabilidade e manuten o do implante. Palavras-chave: Hidroxiapatita. Osseointegra o. Osteog nese. Cetoprofeno. Dexametasona. Effect of dexamethasone and ketoprofen on osteogenesis and bone resistance in rats This study aimed at evaluating the effect of ketoprofen (NSAID) and dexamethasone (SAID) on osteogenesis around a dense hydroxyapatite (DHA) implant in the tibia and parietal bone, and on the bone resistance. Fifteen fifty-day-old Wistar rats weighing on average 250 30 g were used. The animals were separated into three groups (n=5): control (CT); non-steroidal anti-inflammatoryl (NSAID); and steroidal anti-inflammatory (SAID). After anesthesia with IM ketamine/xylazine, a 3 mm cavity was made in the left parietal bone and in the proximal epiphysis of the left tibia. A DHA bioceramic was implanted in the tibia. The animals were treated subcutaneously during 30 days as follows: NSAID group: ketoprofen at the dose of 12/Kg/day; SAID group: dexamethasone, 0,10 mg/ kg/day. The CT group received saline through the same route. All the animals received the same solid diet and water ad libitum. After 30 days of experiment, the animals wereeuthanized, and their femurs collected for the mechanical test, while their tibia and parietal sites were prepared for the histomorphometrical analysis. Microscopically, the SAID and NSAID groups showed a lower volume of neoformed bone. In addition, the NSAID and SAID group femurs required lower maximum force for complete rupture when compared with the CT group. It was concluded that ketoprofen and dexamethasone interfered with osteogenesis and decreased bone resistance by altering the bone tissue metabolism, mainly by inhibiting the COX-2 and decreasing prostaglandins. Therefore, the use of ketoprofen and dexamethasone after bone surgeries can compromise the stability and maintenance of implants. Keywords: Hydroxyapatite. Osseointegration. Osteogenesis. Ketoprofen. Dexamethasone.

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Other references

Wollenberger, Ulla; Wang, Joseph; Scheller, Frieder, 1992, Scheller, F. , Schmid, R. D. Gbf Monographs; Biosensors: Fundamentals, Technologies And Applications: 31-34

Smyth, L. A.; Reynolds, L.; Tyrrell, R.; Williams, O.; Norton, T.; Schumacher, T.; Tybulewicz, V.; Ley, S. C.; Kioussis, D., 1999, Anonymous. Signaling And Gene Expression In The Immune System: 275-282

Waterlow, J. C.; Rutishauser, I. H. E., 1974: It is suggested that the usual method of assessing malnutrition of young children in community surveys as a deficit in weight for age (stunting) and deficit in weight for height (wasting). The problem of reference standards is discussed and a system of classification is proposed which will make it possible to assess the extent of wasting, stunti...

Morrison, R. Ray; Tan, Xing-Lin; Ledent, Catherine; Mustafa, S. Jamal; Hofmann, Polly, A., 2007: Endogenous adenosine is an important ligand trigger for the cardioprotective effects of postconditioning (POC), yet it is unclear which adenosine receptor subtype is primarily responsible. To evaluate the role of A(2A) adenosine receptors in POC-induced protection, global ischemia-reperfusion was performed with and without POC in isolated wild-t...

N. Martins; R. Pereira; N. Abrantes; J. Pereira; F. Gonçalves; C. R. Marques, 2012: Although antibiotics have been increasingly used and detected in natural samples, their ecotoxicological effects on aquatic wildlife are not yet extensively studied. Considering the environmental threat posed by the biological activity of antibiotics it is quite relevant to assess the resulting impact, especially on sub-lethal endpoints. As such...

Daws, Jon, 1992, British Isopod Study Group Newsletter e; 33: 9-10

Mueller, Thomas-Jj, 1999: 3-mono- and 3,7-bis(alkynylated) phenothiazines 7 and 8 can be readily synthesized from the corresponding phenothiazinyl carbaldehydes. The monoalkynylated phenothiazines 7 are dimerized or cross-coupled to give highly fluorescent phenothiazinyl-terminated redox active dumbbells 9 and 10 that display large Stokes shifts. Compound 9 reveals a str...

Wang Ziyu, 1992, Shiyou Shiyan Dizhi = Experimental Petroleum Geology: , Pages 195-199. 1992.

Popova R.P., 1981: From 1976-1979, 1400 viral tests were made in children (84.7%) and adults (15.3%) with diagnosis of acute respiratory diseases [ARD], influenza and pneumonia in sporadic and focal morbidity, during epidemic and interepidemic periods. Five main groups of clinical diagnoses were isolated: ARD, influenza, acute pneumonia, keratoconjunctivitis and p...

Gunther, Ho, 1975, Zeitschrift feur Lebensmittel Untersuchung und Forschung: 58 (1) 9-20