A study of genetic polymorphisms of milk beta-lactoglobulin, alpha s1-casein, beta-casein, and kappa-casein in five dairy breeds

Li, F.H.; Gaunt, S.N.

Biochemical Genetics 6(1): 9-20

1972


ISSN/ISBN: 0006-2928
PMID: 4666751
DOI: 10.1007/bf00485960
Accession: 000009676

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Abstract
Gene frequencies of milk beta -lactoglobulin, alpha s1-, beta - and kappa -casein loci have been estimated from 1663 cows of 5 dairy breeds. Departure from Hardy-Weinberg equilibrium [P < 0.05] was found only in the kappa -casein system in Jerseys. However, chance alone could have accounted for this single significant finding. Results of pairwise comparisons among the 5 breeds of allele frequencies at these milk protein loci indicated that of the 40 possible tests, only 6 comparisons were not significant at the 5% probability level. It would appear that these breeds were characterizable in terms of the gene frequencies of these milk protein loci. Non-independent assortment of genotypes among these milk protein loci was also studied. The closely linked casein loci were non-independent in almost all the breeds where tests could be carried out; the only exception was between the alpha s1- and kappa -casein loci in Holstein-Friesians. BETA -Lactoglobulin was independent of the casein loci in all breeds except Brown Swiss, where it was found to be significantly [P < 0.1] associated with kappa -casein. Close linkage is proposed as an important factor for maintaining the observed milk protein polymorphisms.

A study of genetic polymorphisms of milk beta-lactoglobulin, alpha s1-casein, beta-casein, and kappa-casein in five dairy breeds