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Comparative clinical trial of bitoscanate, bephenium hydroxynaphthoate and tetrachloroethylene in hookworm infection



Comparative clinical trial of bitoscanate, bephenium hydroxynaphthoate and tetrachloroethylene in hookworm infection



Indian Journal of Medical Sciences 26(11): 718-722



In a controlled trial bitoscanate (3 doses of 100 mg after meals 12 hours apart for those over 45 kg in body-weight, and 2 doses of 100 mg after meals for those under that weight), or bephenium hydroxynaphthoate (2.4 g of base as a single oral dose) or tetrachloroethylene (3 ml as a single oral dose) were each given to 23 patients with hookworm infection. Faecal egg counts were performed using Stoll's method for 3 consecutive days before and for 3 consecutive days 4 weeks after treatment. The 3 compounds cured 15, 3 and 5 patients, respectively, and reduced egg counts by 98, 76 and 89%. Mild reactions were encountered with all 3, but more frequently in the case of bitoscanate.

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Accession: 000044610

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PMID: 4654414



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