Section 1
Chapter 46

Comparative scrapie activity of brain material and cerebrospinal fluid from scrapie-affected rats

Chandler, R.L.; Harrison, R.

British Veterinary Journal 130(0): Xliv-Xlvi


ISSN/ISBN: 0007-1935
PMID: 4210058
DOI: 10.1016/s0007-1935(17)35951-1
Accession: 000045242

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Clinical scrapie was produced with a 10-6 dilution of scrapie brain material, but no scrapie was produced with a 10-2 dilution of scrapie cerebrospinal fluid used as inoculum. The results suggest the existence of a barrier against ready transfer of scrapie agent from those parts of the brain where it exists in relatively high concentration into the cerebrospinal fluid space.

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