Effect of schistosomal infection and of schistosomicidal drugs on the drug metabolizing enzymes of mouse liver
Ghazal, A.; Mahfouz, M.; Makar, A.B.; Ghoneim, M.T.
Naunyn-Schmiedeberg's Archives of Pharmacology 282(2): 181-186
ISSN/ISBN: 0028-1298 PMID: 4368632 DOI: 10.1007/bf00499032
Infection of mice with Schistosoma mansoni was found to inhibit all the drug metabolizing enzyme activities studied; monomethylaminoantipyrine (MMAA)N-demethylating and paraoxon hydrolysing activities were strongly inhibited but hexobarbital and aniline metabolizing activities were only moderately affected. Treatment of infected mice with tartar emetic, stibophen and niridazole produced a dramatic reversal in the inhibition of MMAA and paraoxon metabolising enzymes. Lucanthone HCl did not have a marked effect on the inhibition of these 2 enzymes and none of the drugs had any statistically significant effect on the inhibition of hexobarbital and aniline metabolizing activities.