Section 1
Chapter 75

Effect of schistosomal infection and of schistosomicidal drugs on the drug metabolizing enzymes of mouse liver

Ghazal, A.; Mahfouz, M.; Makar, A.B.; Ghoneim, M.T.

Naunyn-Schmiedeberg's Archives of Pharmacology 282(2): 181-186


ISSN/ISBN: 0028-1298
PMID: 4368632
DOI: 10.1007/bf00499032
Accession: 000074709

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Infection of mice with Schistosoma mansoni was found to inhibit all the drug metabolizing enzyme activities studied; monomethylaminoantipyrine (MMAA)N-demethylating and paraoxon hydrolysing activities were strongly inhibited but hexobarbital and aniline metabolizing activities were only moderately affected. Treatment of infected mice with tartar emetic, stibophen and niridazole produced a dramatic reversal in the inhibition of MMAA and paraoxon metabolising enzymes. Lucanthone HCl did not have a marked effect on the inhibition of these 2 enzymes and none of the drugs had any statistically significant effect on the inhibition of hexobarbital and aniline metabolizing activities.

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