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Effects of the epidermal chalone on DNA synthesis in mammalian epidermal cells

Journal of Investigative Dermatology 60: 160-165

Effects of the epidermal chalone on DNA synthesis in mammalian epidermal cells

The rate of incorporation of tritiated thymidine (3H-TdR) was used to measure the synthetic capabilities of pig epidermal cells in vitro in the presence of ethanolie fractions of a tissue-specific mitotic inhibitor (chalone). In control cultures, a synthetic lag period of approx. two hrs was followed by a period of maximal DNA synthesis at 4 hrs incubation.

Accession: 000081088

Related references

Wiley, C.L.; Williams, W.W.; McDonald, C.J., 1973: The effects of the epidermal chalone on DNA synthesis in mammalian epidermal cells. Journal of Investigative Dermatology 60(3): 160-165

Bertsch, S.; Marks, F., 1979: Effects of epidermal chalone and epidermal growth factor on a transplantable epidermal carcinoma (Hewitt) of the mouse in vivo. The effects of chalone-containing skin preparations and of epidermal growth factor on the proliferative activity of a transplantable nonkeratinizing epidermal carcinoma (Hewitt) of the mouse were studied in vivo. Whereas crude skin extracts suppre...

Schweizer, J.; Marks, F., 1978: Lack of relationship between Langerhans cells, epidermal cell proliferation and epidermal G1 chalone. Mouse tail interscale epidermis contains numerous Langerhans cells, whereas the adjacent scale regions are devoid of these cells. No difference in a) proliferative activity and b) inhibitory effect of the epidermal G1 chalone can be demonstrated i...

Delescluse, C.; Pruniéras, M., 1971: Effect of a chalone type aqueous epidermal extract on epidermal cells in culture. Annales de Dermatologie et de Syphiligraphie 98(5): 533-535

Kariniemi, A.L., 1977: Effect of cell growth inhibiting factors, epidermal chalone and interferon, on the proliferation of epidermal cells. The diffusion chamber technique was used to culture human epidermal cells derived from psoriatic and non-psoriatic skin. The effect of epidermal chalone and human leukocyte interferon on the cell proliferation of human epidermal cells was studied...

Kariniemi, A.L., 1976: Chalone-induced inhibition in DNA synthesis of human psoriatic epidermal cells cultured in diffusion chambers in mice. Pieces of human psoriatic skin and suspensions of mouse bone marrow cells as non-epidermal control tissue were cultured for four days in diffusion chambers implanted intraperitoneally in 40 mice. The mice were divided into three groups. On the sec...

Bullough W.S.; Laurence E.B., 1968: Control of mitosis in rabbit neopl vx2 epidermal tumors by means of the epidermal chalone. European Journal of Cancer 4(6): 587-594

Richter, K.H.; Clauss, M.; Höfle, W.; Schnapke, R.; Marks, F., 1988: The epidermal G1-chalone: an endogenous tissue-specific inhibitor of epidermal cell proliferation. An apparently macromolecular factor is isolated from aqueous skin extracts which inhibits DNA synthesis in vivo and in vitro with high efficacy (ID50 in vivo 0.2 pmol/g, in vitro 0.2 pM) and in a highly specific manner showing a point of attack in...

Elgio, K., 1973: Epidermal chalone: cell cycle specificity of two epidermal growth inhibitors. National Cancer Institute Monograph 38: 71-76

Elgio K., 1973: Epidermal chalone cell cycle specificity of 2 epidermal growth inhibitors. Forscher, Bernard K And John C Houck (Ed ) National Cancer Institute Monograph, No 38 Chalones: Concepts And Current Researches Proceedings Of The 1st Symposium Of The International Chalone Conference Augusta, Mich , U S A , June 5-7, 1972 Viii+233p Illus U S Department Of Health, Education, And Welfare, National Cancer Institute: Bethesda, Md , U S A 71-76