Pathological changes caused by experimental trypanosomiasis in mice, rats, and guinea-pigs

Ibadullaev, F.I.; Khalikov, F.R.

Trudy Uzbekskogo Nauchno issledovatel' skogo Veterinarnogo Institut 20: 70-72


Accession: 000156805

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Thirty mice, 20 rats, and 10 guinea-pigs were infected with the camel trypanosome, Trypanosoma ninaekohljakimovi. Mice and rats were given 0.5 ml i/v, guinea pigs 1 ml s/c. In mice, trypanosomes appeared in peripheral blood on the 2nd day, in rats on the 4th day, and in guinea-pigs on the 10th. Mice were most severely affected, clinical signs were loss of appetite, drowsiness, photophobia; and later blindness, paralysis of hind legs and emaciation. Rats showed depressed respiration, drowsiness, anaemia and inappetence. Guinea-pigs showed anaemia, increased pulse and respiration, increased temperature (to 39 deg C), and loss of appetite. All the animals died-mice after 5-6 days, rats after 18-20 days, guinea-pigs after 5 weeks or more. P.M. changes were mainly found in liver, spleen and kidneys. Liver was icteric and shrunken with petechial haemorrhages. Kidneys were swollen and haemorrhagic. The spleen was 2-3 times larger, dark red, and the parenchymatous part was indistinguishable. Other signs found at P.M. were yellow peritoneal fluid, anaemic mucous membranes and slowing of putrefaction.