Stimulatory effect of pancreozymin-cholecystokinin on calcium secretion in pancreatic juice of dogs

Goebell, H.; Steffen, C.; Bode, C.

Gut 13(6): 477-482


ISSN/ISBN: 0017-5749
PMID: 5040835
DOI: 10.1136/gut.13.6.477
Accession: 000201651

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In 4 dogs with a permanent duodenal Thomas fistula the secretion of Ca, Na, K, protein and 2 pancreatic enzymes in pancreatic juice was studied. Infusion of secretin led to a decrease in the concentration of Ca and protein with increasing rates of fluid production. Pancreozymin with cholecystokinin was given in single injections superimposed on the secretin-stimulated flow of juice. This hormone stimulated the secretion of Ca and enzyme protein in a parallel and closely correlated fashion (r = 0.95). The secretion of protein-bound Ca fraction I was assumed to occur in the acinar cell. A Ca fraction II, which was independent of protein secretion and pancreozymin stimulation, was demonstrated in concentrations of about 0.4 to 0.6 m-equiv/litre. This fraction was thought to originate in the interstitial fluid.