Synthesis of nicotinamide adenine dinucleotide phosphate and its control in rat tissues by administration of nicotinic acid

Khalmuradov, A.G.; Shushevich, S.I.; Fomenko, G.I.

Ukrainskii Biokhimichnii Zhurnal 44(3): 275-282


Accession: 000213930

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Nicotinic acid 150 mg/kg bodyweight given to rats led to increased formation of NADP+ in liver and kidneys; the peak in the liver after 9 h was 2.4 times the initial rate, that in kidneys a threefold increase in concentration. In 24 h both concentations had returned to initial values. There was a correlation of NADP+ content with NAD kinase activity. The response to nicotinic acid was inhibited by ethionine or 6-mercaptopurine, evidence for a regulatory role of ATP in synthesis of NADP+. It was not altered by chloramphenicol or actinomycin D used as inhibitors of protein synthesis. It was concluded that NAD kinase of rat liver is not an adaptive enzyme (from summaries).