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The effect of hypophysectomy and subsequent replacement therapy with sheep prolactin or bovine growth hormone on the lactose synthetase activity of rabbit mammary gland



The effect of hypophysectomy and subsequent replacement therapy with sheep prolactin or bovine growth hormone on the lactose synthetase activity of rabbit mammary gland



Biochemical Journal 130(4): 997-1002



There was an approx. 4-fold decline in the lactose synthetase activity of lactating rabbits' mammary gland homogenates, calculated on a DNA basis, within 6-7 days of hypophysectomy. Sheep prolactin reversed this decline but growth hormone had no effect. Changes in the properties of a particulate fraction isolated from the glands indicated that a decline in the effective concn. of alpha -lactalbumin was one factor contributing to the decreased lactose synthetase activity after hypophysectomy.

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Accession: 000226091

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PMID: 4656808

DOI: 10.1042/bj1300997


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