Section 1
Chapter 250

The white rat and golden hamster as experimental hosts for Brugia pahangi and subperiodic Brugia malayi

Harbut, C.L.

Southeast Asian Journal of Tropical Medicine and Public Health 4(4): 487-491


ISSN/ISBN: 0125-1562
PMID: 4787649
Accession: 000249358

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Golden hamsters were evaluated as hosts for Brugia pahangi and sub-periodic B. malayi and white rats as hosts of B. pahangi only. In rats, the 3rd moult of B. pahangi occurred at 7 to 9 days, and the final moult, observed only in male worms, took place about 25 days after inoculation. Microfilaraemia occurred in 18 of 33 rats and 7 of 11 hamsters inoculated with B. pahangi and observed longer than 55 days. Prepatent periods ranged from 55 to 105 days (mean 69) in rats and from 62 to 97 days (mean 81) in hamsters. Microfilaraemia rates seldom exceeded 12 mf/20mm3 of blood in rats or 28 mf/20mm3 in hamsters. Rates of 41 and 60 mf/20mm3 were, however, detected in 2 rats. Adult B. pahangi were primarily localized in the heart and lungs of rats and in the lungs and testes of hamsters. All 9 hamsters inoculated with B. malayi and observed for 141 days failed to develop patent infections although adult worms occurred within the testes and/or heart and lungs. [AS].

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