Transmissible gastroenteritis. Mechanisms responsible for diarrhea in an acute viral enteritis in piglets

Butler, D.G.; Gall, D.G.; Kelly, M.H.; Hamilton, J.R.

Journal of Clinical Investigation 53(5): 1335-1342

1974


ISSN/ISBN: 0021-9738
PMID: 4825228
Accession: 000252803

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
Use of continuous segmental marker perfusion in four regions along the intestines of 3-week-old piglets which, 40 hours earlier, had been infected with transmissible gastroenteritis (TGE) virus showed that increase of net intraluminal accumulation of water and electrolytes occurred only in the proximal jejunum-the region known to be the site of TGE infection. Gross structure of the villi, intraluminal bacteria, bile salts, lactate, pH and osmolality were not affected by the infection. Although this work did not reveal the mechanism which caused the influx to the jejunum, it may be that replacement of cells shed from the tips of the villi by cells from the crypts is too fast; crypt cells are normally secretory and may contribute to the sodium secretion which occurred.