+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540) a new anthelmintic with potent antihookworm activity



4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540) a new anthelmintic with potent antihookworm activity



Acta Tropica 33(1): 101-102



Amongst several hundred isothiocyanates screened, 4-isothiocyanato-4'-nitrodiphenylamine was found to be highly promising against both adult and immature stages of Necator americanus in hamster. Single oral doses of 30 to 60 mg/kg body-weight eliminated 94 to 99% of the parasites in a 37-day-old non-patent infection. Single oral doses of 25 mg/kg and above, completely eliminated the worms in adult mature patent infections. It is suggested that the drug paralyses the worms. Tests in mice have shown that 90 to 200 mg/kg can completely expel Nematospiroides dubius and Hymenolepis nana. In dogs hookworm and ascarid faecal egg counts were reduced by 90 to 100% by 25 mg/kg.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 000267962

Download citation: RISBibTeXText

PMID: 13629


Related references

Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic. British Journal of Clinical Pharmacology 4(4): 463-467, 1977

Systolic time intervals in chronic anaemia before and after 4-isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540). A new anthelmintic. Journal of the Association of Physicians of India 29(2): 109-113, 1981

Clinical trials of a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), for the cure of hookworm infection. American Journal of Tropical Medicine and Hygiene 26(4): 636-639, 1977

New potent, broad spectrum anthelmintic 4-isothiocyanato-4'-nitrodiphenylamine (CG 9333-Go). Abstracts of the 1st National Congress for Parasitology, Baroda, 24-26 February 1977: 58-59, 1977

4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-Go/CGP 4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes. Experientia 32(4): 457-458, 1976

4-Isothiocyanato-4'-nitrodiphenylamine (C 9333-GoCGP 4540), an antischistosomal compound with an unusual spectrum of anthelminthic activity against intestinal nematodes, filariae and trematodes. Advances in pharmacology and therapeutics Volume 10 Chemotherapy Proc 7th Internat Congr Pharmacology, Paris 1978: 17-26, 1979

Clinical evaluation of a new anthelmintic - C.9333 Go./CGP 4540 in human hookworm infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 71(3): 247-250, 1977

Chemotherapeutic effects of 4-isothiocyanato-4'-nitrodiphenylamine (C9333-Go/CGP 4540) on infections with Nematospiroides dubius, Hymenolepis diminuta, Hymenolepis nana and Spirometra mansonoides. Experientia 35(2): 243-244, 1979

Anthelmintic efficacy of amoscanate (C 9333-Go/CGP 4540) against various infections in rodents, dogs and monkeys. American Journal of Tropical Medicine and Hygiene 30(5): 992-998, 1981

Serum cholesterol in hookworm infection before and after a new anthelmintic - amoscanate (C. 9333 GO/CGP 4540). A methodological lesson for phase 2 drug trials. Indian Journal of Parasitology 10(2): 165-169, 1986