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Adoptive transfer of immunity to Plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide



Adoptive transfer of immunity to Plasmodium berghei by a population of immune rat spleen cells resistant to cyclophosphamide



International Journal of Parasitology 6(2): 103-106



Spleen cells were collected from normal rats and from rats immune to Plasmodium berghei and were injected intravenously into syngeneic rats. These were then challenged by inoculation with P. berghei. Both kinds of cells induced an accelerated antibody response to the infection as measured by fluorescent antibody but only immune cells induced marked protection. Pretreatment of normal or immune donor rats with cyclophosphamide markedly depleted their spleens but did not reduce the antibody stimulation or the protection.

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Accession: 000282890

Download citation: RISBibTeXText

PMID: 770355

DOI: 10.1016/0020-7519(76)90063-1



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