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An attempt to use helanine in the treatment of experimental trichinelliasis of guinea pigs



An attempt to use helanine in the treatment of experimental trichinelliasis of guinea pigs



Zeszyty Naukowe Wyzszej Szkoly Rolniczej we Wroclawiu (63): 131-139



Guinea-pigs were infected with 500 Trichinella spiralis each and treated with helenine (an Inula helenium root extract containing alantolactone) to test its effect on the intestinal stages. At autopsy 60 to 80 days after infection, those receiving 100 mg/kg helenine daily for 30 days had 7.4% fewer muscle larvae than the untreated controls, those receiving 300 mg/kg for 10 days had 62.6% fewer larvae and those given a single, toxic dose of 2,500 mg/kg had 77.3% fewer larvae.

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