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Chemical and immunological characterization of specific glycoproteins from Trypanosoma equiperdum variants

Chemical and immunological characterization of specific glycoproteins from Trypanosoma equiperdum variants

FEBS Letters 82(1): 93-96

Purified clone-specific glycoproteins were isolated from 5 antigenic variants of Trypanosoma equiperdum and were analysed chemically. All were rich in aspartate, glutamate, threonine, alanine and lysine but they differed greatly in their leucine content. They contained glucose, mannose, galactose and N-acetylglucosamine. The 3 sugars were present in constant amounts and proportions. Probably the carbohydrates are exposed on the surface of the parasites and play an important role in host-parasite relationships. Hyperimmune sera prepared against one glycoprotein gave no reaction with the others showing the immunological purity of those glycoproteins. Clone-specific protection was given to mice against challenge with homologous but not heterologous trypanosomes.

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Accession: 000313458

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PMID: 913583

DOI: 10.1016/0014-5793(77)80893-4

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