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Copper:molybdenum interaction. Effect of dietary molybdenum on the binding of copper to plasma proteins in sheep



Copper:molybdenum interaction. Effect of dietary molybdenum on the binding of copper to plasma proteins in sheep



Journal of Comparative Pathology 85(2): 299-305



For 203 days 4 groups of 3 Scotch Blackface wether sheep were given diets adequate in Cu without or with 8, 16 or 24 mu g Mo/g. All were then given the diet without the Mo supplement for a further 21 days and blood samples were taken at intervals throughout. Sheep given Mo up to 8 mu g/g showed no change in plasma Cu distribution. Diets with 16 and 24 mu g added Mo/g produced changes in plasma Cu distribution, the extent of which was similar for both diets; the changes were complete within about 12 days and when Mo supplement was withdrawn they were reversed in a similar period. The Mo produced an increase in total plasma Cu and direct-reacting Ca, no change in absolute concentration of caeruloplasmin Cu, but a decrease as a proportion of total plasma Cu. About a third of the plasma Cu was insoluble in trichloroacetic acid and some of this fraction seemed to be estimated as direct-reacting Cu.

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Accession: 000327708

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PMID: 1141465



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