Effect of ethanol on utilization of plasma free fatty acids for liver triacylglycerol synthesis and its relation to hepatic triacylglycerol accumulation in rats
Johnson, O.; Hernell, O.; Olivecrona, T.
Lipids 10(12): 765-769
ISSN/ISBN: 0024-4201 PMID: 1207412 DOI: 10.1007/bf02532318
The effects of ethanol on the utilization of plasma free fatty acids and the accumulation of triacylglycerol in the liver were studied in 2 experiments with female Sprague-Dawley rats, weighing 140 to 160 g. The rats were intubated with 38% ethanol in water, 2.00, 3.75 or 6.0 g/kg bodyweight. In the first experiment a fatty acid-albumin complex 0.5 ml, containing leic acid was given by vein immediately and 6 or 16 h after treatment; in the second experiment no radioactive fatty acid was given. All treatments caused a rapid increase in the liver triacylglycerol concentration during the first 5 h after enthanol; the amounts were independent of the quantity of ethanol given.