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Chapter 351

Effect of ethanol on utilization of plasma free fatty acids for liver triacylglycerol synthesis and its relation to hepatic triacylglycerol accumulation in rats

Johnson, O.; Hernell, O.; Olivecrona, T.

Lipids 10(12): 765-769

1975

ISSN/ISBN: 0024-4201
PMID: 1207412
DOI: 10.1007/bf02532318
Accession: 000350099
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The effects of ethanol on the utilization of plasma free fatty acids and the accumulation of triacylglycerol in the liver were studied in 2 experiments with female Sprague-Dawley rats, weighing 140 to 160 g. The rats were intubated with 38% ethanol in water, 2.00, 3.75 or 6.0 g/kg bodyweight. In the first experiment a fatty acid-albumin complex 0.5 ml, containing leic acid was given by vein immediately and 6 or 16 h after treatment; in the second experiment no radioactive fatty acid was given. All treatments caused a rapid increase in the liver triacylglycerol concentration during the first 5 h after enthanol; the amounts were independent of the quantity of ethanol given.

Effect of ethanol on utilization of plasma free fatty acids for liver triacylglycerol synthesis and its relation to hepatic triacylglycerol accumulation in rats

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