Effect of ethynyl estradiol on the secretion of hepatic triglyceride

Weinstein, I.; Seedman, S.; Veldhuis, M.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 149(1): 181-184


ISSN/ISBN: 0037-9727
PMID: 1144424
DOI: 10.3181/00379727-149-38768
Accession: 000350156

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Female Sprague-Dawley rats of bodyweight 190 to 240 g were fed on powdered Purina laboratory diet and given sesame oil alone (control) or with ethynyl oestradiol 5 or 15 mu g/kg bodyweight daily for 14 days. The livers were perfused with a medium containing defibrinated rat blood, Krebs-Henseleit bicarbonate buffer, pH 7.4, and after a stabilising period palmitic acid with bovine serum albumin was infused. Triglycerides, cholesterol and glucose were estimated in aliquots of erythrocyte-free perfusate. The concentrations of triglyceride in blood rose 2- and 4-fold with the oestradiol at 5 and 15 mu /kg bodyweight. The rate of secretion of triglyceride increased 66% over controls with either dose of ethynyl oestradiol. Ethynyl oestradiol induced hypocholesterolaemia in the donor rats but the secretion of cholesterol into the perfusate from livers obtained from those rats was not affected. Adrenal corticosterone concentrations were depressed by 48% in rats given ethynyl oestradiol.