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Effect of ultra low-volume aerial spray of phosphomidon (organophosphorous insecticide) on human volunteers: a field surveillance study



Effect of ultra low-volume aerial spray of phosphomidon (organophosphorous insecticide) on human volunteers: a field surveillance study



Indian Journal of Medical Research 64(4): 579-583



Toxicological effects of ultra-low volume (ULV) aerial spray of phosphamidon, a highly toxic organophosphorus insecticide, were evaluated in 38 human volunteers. Results of medical surveillance and serial estimation of pre- and post-exposure blood cholinesterase [ChE] enzyme activity in red cell and plasma were reported. A single ULV aerial application of phosphamidon in doses of 550 g/ha produced irritation of eyes and conjunctivae in the majority of cases, at the time of insecticidal application. No other clinical manifestations were noticed. Observations on blood plasma ChE activity showed a significant depression in 75% of the volunteers. This was noticed on the 3rd day of application and the activity gradually recovered by the 9th day. The inhibition of red cell ChE activity was not significant.

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Accession: 000358190

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PMID: 965057


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