Evaluation of blood urea nitrogen and serum creatinine concentrations as indicators of renal dysfunction: a study of 111 cases and a review of related literature

Finco, D.R.; Duncan, J.R.

Journal of the American Veterinary Medical Association 168(7): 593-601


ISSN/ISBN: 0003-1488
PMID: 1270342
Accession: 000370341

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In this study, azotaemia was assumed to be present if blood urea nitrogen (BUN) was >35 mg/100 ml or if serum creatinine (SC) was >1.5 mg/100 ml, regardless of species. Eighty-seven dogs and 24 cats were used, all of which were cases of naturally occurring azotaemia except for 8 cats which had induced urethral obstruction. Those with pre-renal factors such as dehydration or cardiovascular disease, no kidney lesions and specific gravity of urine >1.025, with no post-renal obstruction were classified as pre-renal cases. Post-renal azotaemia was assumed if outflow obstruction was present, there was no evidence of renal disease, or if BUN and SC returned to normal after removing any obstruction. Primary renal azotaemia was diagnosed when severe generalized renal disease was present or the animal could not concentrate urine. Differentiation of renal from extrarenal azotaemia was not possible from the BUN:SC ratio; BUN and SC should be regarded as crude indices of renal function; single determinations provide no basis for prognosis.