Evidence for a role of androgens in the growth and maturation of ovarian follicles in rats

Kumari, G.L.; Datta, J.K.; Roy, S.

Hormone Research 9(2): 112-120


ISSN/ISBN: 0301-0163
PMID: 564325
DOI: 10.1159/000178903
Accession: 000372002

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Changes in the morphology and steroid content of ovaries relative to untreated controls were studied 48 h after intravenous injection of 100 mu g cyproterone acetate or flutamide (both anti-androgens) to dioestrous or oestrous rats. 7 females /group were used. Treatment with cyproterone acetate at dioestrus caused a decrease in the numbers of small follicles (<200 mu in diameter) and freshly formed corpora lutea, and in the levels of oestradiol-17 beta in the ovary, suggesting inhibition of ovulation. Following flutamide administration at dioestrus, the numbers of follicles at all stages of development were reduced, with a concomitant decrease in the ovarian levels of the hormone. Thus, flutamide suppressed the growth and maturation of follicles, indicating that androgens are implicated in follicle growth. On administration of the anti-androgens at oestrus, the steroid content of the ovaries increased with the increase in the number of mature and medium follicles.