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Induction of ovulation during the postpartum period in the Thoroughbred mare with a prostaglandin analogue, Synchrocept



Induction of ovulation during the postpartum period in the Thoroughbred mare with a prostaglandin analogue, Synchrocept



Theriogenology 6(4): 403-412



Breeding of mares at the foal heat is desirable, but the low pregnancy rate and the not infrequent occurrence of subsequent anestrus are a deterrent. A PGF2.alpha. [prostaglandin F2.alpha.] analog, Synchrocept (prostalene), as a single 2 mg s.c. injection was used to induce ovulation, either during the corpus luteum phase subsequent to a foal heat (test group 1) or at a fixed interval of 20 days from parturition (test group 2) in mares that also had a foal heat. Mares with no signs of a foal heat were treated 20 days postpartum (test group 3). A total of 80 mares, mostly thoroughbred, were treated in more than 15 breeding centers in Northern Germany between mid-Jan. and mid-May 1975. At the same locations and over the same time periods, 60 control mares (control group 1) were bred at the foal heat, and 40 additional control mares (control group 2) were bred later than 25 days postpartum. In groups 1 and 2, treatment induced estrus in 95% of the mares, and in group 3 estrus was induced in 68% of the mares. Of these animals, 92% were bred, and 81% conceived on the average 28 days after parturition. The number of services per conception in mares treated was 25% lower (2.5) than in controls (3.2). Synchrocept acted as a luteolysin, but seems also to have induced heat and estrus in animals with plasma progesterone levels below 1 ng/ml, as reported previously. Neither mares nor foals showed detectable clinical signs of drug intolerance.

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Accession: 000404966

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DOI: 10.1016/0093-691x(76)90107-2


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