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Interactions between Toxoplasma gondii and its host cells: function of the penetration-enhancing factor of toxoplasma

Interactions between Toxoplasma gondii and its host cells: function of the penetration-enhancing factor of toxoplasma

Infection and Immunity 11(4): 853-861

These workers believe that the entry of Toxoplasma gondii into host cells depends upon a penetration enhancing factor (PEF). This has now been identified as a protein with a molecular weight of 70,000 to 150,000. Activity was greatest at 37 deg C and pH 7.6 and was dependent on Ca and Mg. Under these conditions as little as one ng was effective. Experiments on the infection of HeLa cells showed that PEF is specific for Toxoplasma and does not affect the uptake of other particulate material.

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Accession: 000411578

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PMID: 1120615

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