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Mechanism of chloroquine induced involuntary movements

Mechanism of chloroquine induced involuntary movements

British Medical Journal 1(6072): 1350

ISSN/ISBN: 0007-1447

PMID: 861620

DOI: 10.1136/bmj.1.6072.1350-b

In a previous report Umez-Eronini & Eronini had described involuntary movements occurring in persons taking chloroquine for malaria. The present author points out that chloroquine combines with melanin which is a derivative of DOPA (dihydroxyphenylalanine). He suggests that in the brain, chloroquine combines with dopaminergic receptors in the nigrostriatal system, blocking them and thus producing involuntary movements. This would be another example of drug-induced extrapyramidal disorders.

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Accession: 000427827

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