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Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic



Phase 1 tolerability and searching dose studies with 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), a new anthelmintic



British Journal of Clinical Pharmacology 4(4): 463-467



Three doses of 4-isothiocyanato-4'-nitrodiphenylamine at 125, 250 or 1,000 mg at 12- or 8-hour intervals were highly effective against hookworm (Necator americanus and/or Ancylostoma duodenale) in trials with 30 patients in India. Faecal egg counts were reduced to zero in all but 2 patients and worms were voided in the faeces. Simple doses were relatively ineffective. The drug was active also against Ascaris, Trichuris and Enterobius.

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Accession: 000456679

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PMID: 901739


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