Reduction of aflatoxin B2a with sodium borohydride
Reduction of aflatoxin B2a with sodium borohydride
Ashoor, S.H.; Chu, F.S.
Journal of Agricultural and Food Chemistry 23(3): 445-447
1975
ISSN/ISBN: 0021-8561
PMID: 239038
DOI: 10.1021/jf60199a060
Limited production of aflatoxin B2a with sodium borohydride at neutral or slightly alkaline pH resulted in a new derivative, reduced aflatoxin B2a(RB2a), the properties of which are described. Prolonged incubation of RB2a with NaBH4 results in further reduction of the compound. The data support the proposed structural changes of B2a in which a phenolate ion is formed and 2 aldehyde groups are generated in basic sol. Reduced aflatoxin B2a was not toxic to chicken embryos at levels X 100 the LD50 of B1.