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Resistance to infection with Schistosoma mansoni after immunization with worm extracts or live cercariae: role of cytotoxic antibody in mice and guinea pigs

Resistance to infection with Schistosoma mansoni after immunization with worm extracts or live cercariae: role of cytotoxic antibody in mice and guinea pigs

American Journal of Tropical Medicine and Hygiene 24(6 Pt 1): 955-962

Mice and guinea-pigs were immunized with adult and cercarial extracts of Schistosoma mansoni prepared in different ways. Most animals responded by producing moderate to high levels of cytotoxic antibody, but no correlation with resistance to infection could be detected. Initial experiments with a 3M KCl adult extract and with cercarial exoantigen produced partial resistance; several attempts to reproduce those results failed.

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Accession: 000485107

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PMID: 1200260

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