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Respiratory stimulant action of S 2620 in the dog anaesthetized with pentobarbital



Respiratory stimulant action of S 2620 in the dog anaesthetized with pentobarbital



Comptes Rendus des Seances de la Societe de Biologie 169(6): 1579-1584



In the dog under pentobarbitone anaesthesia, the i/v injection of 1 mg/kg S 2620 is followed by a significant increase in respiratory rate, PaO2 and pHa and by a large decrease in PaCO2. Cervical vagotomy and chemoreceptor denervation reduced and even abolished these effects. They can be induced again by a second i/v injection or by direct instillation in the fourth ventricle.

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Accession: 000485366

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