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Response of bovine ovarian arterial smooth muscle to prostaglandin F2 alpha and neurotransmitter



Response of bovine ovarian arterial smooth muscle to prostaglandin F2 alpha and neurotransmitter



Journal of Animal Science 45(5): 1091-1095



A segment of artery supplying each ovary was removed from eight beef heifers on day 17 of the oestrous cycle, noting which artery was ipsilateral and which was contralateral to the ovary containing the largest follicle and greatest amount of follicular fluid. In five of eight heifers, the ovary with the greater follicular development also contained the corpus luteum. Each arterial segment was perfused with oxygenated Krebs Henseleit solution prior to initiating sequential 10-min perfusions of saline and agents which enhance (PFG and norepinephrine) or suppress (phentolamine) vasoconstriction. At the end of each perfusions, vasoconstriction was provoked by periarterial nerve stimulation. PGF tromethamine salt (1 ng salt/ml) only enhanced constriction of ipsilateral arteries. Although perfusion of norepinephrine (500 ng/ml) increased constriction of both ipsilateral and contralateral arteries, the response of ipsilateral arteries to this neurotransmitter exceeded that of contralateral arteries. Phentolamine (100 ng/ml) blocked constriction of all arteries. Subsequent perfusion of PGF and stimulation failed to elicit an increase in constriction over that following the perfusion of phentolamine. Perfusion of norepinephrine after PGF displaced bound phentolamine and resulted in only ipsilateral arteries responding to stimulation with increased constriction. Ovarian function evidently influences the ability of the ipsilateral ovarian artery to respond to vasoconstrictors.

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Accession: 000485535

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PMID: 599098



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