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Response of plasma insulin to small doses of tolbutamide in obesity and acromegaly



Response of plasma insulin to small doses of tolbutamide in obesity and acromegaly



International Journal of Obesity 1(4): 315-324



The early response of plasma insulin (IRI) to successive intravenous doses of 50, 100 and 200 mg tolbutamide was studied in nondiabetic obese subjects, in acromegalic patients and in healthy controls. The smallest dose increased plasma IRI within 2 min in all subjects. The insulin response was correlated with basal IRI in controls and in obese subjects but not in acromegalic patients. At each tolbutamide dose the mean IRI response of obese subjects was about 3 times that in controls.

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Accession: 000485829

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PMID: 617112


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