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Serologic response to canine distemper viral antigens in gnotobiotic dogs infected with canine distemper virus

Krakowka, S.; Olsen, R.; Confer, A.; Koestner, A.; McCullough, B.

Journal of Infectious Diseases 132(4): 384-392

1975


ISSN/ISBN: 0022-1899
PMID: 1185008
DOI: 10.1093/infdis/132.4.384
Accession: 000495405

The humoral immune response to canine distemper viral antigens in gnotobiotic dogs experimentally infected with canine distemper virus (CDV) was studied by the CF and serum neutralization tests. Antibody titres measured by both serological methods varied inversely with the severity of disease produced. Recovered dogs exhibited the highest titres of antibody, whereas fatally infected dogs had little or no antibody activity in their serum.

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