Section 1
Chapter 523

Teratogenicity of patulin and patulin adducts formed with cysteine

Ciegler, A.; Beckwith, A.C.; Jackson, L.K.

Applied and Environmental Microbiology 31(5): 664-667


ISSN/ISBN: 0099-2240
PMID: 1275488
Accession: 000522743

The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mu g and that for the 4-day-old embryo 2.35 mu g. Both patulin (1-2 mu g/egg) and the reaction mixture between patulin and cysteine (15-150 mu g of patulin equivalents) were teratogenic to the embryo. At least 2 ninhydrin-negative and 4 ninhydrin-positive products were formed during the latter reaction.

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