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The effect of diet on hepatic bile formation and bile acid metabolism in squirrel monkeys with and without cholesterol gallstones



The effect of diet on hepatic bile formation and bile acid metabolism in squirrel monkeys with and without cholesterol gallstones



Journal of Laboratory and Clinical Medicine 88(4): 649-661



In order to study why squirrel monkeys on some experimental diets develop cholesterol gallstones, measurements were made of bile acid kinetics and bile secretion and composition. The pool size of cholic acid was much greater in monkeys on a commercial diet than on a semipurified diet. It was also greater in squirrel monkeys on a lithogenic diet but without gallstones than in monkeys from the same diet group with gallstones.

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Accession: 000533162

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PMID: 823283


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