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The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense. II. Survey of strains from East Africa and Nigeria



The resistance to human plasma of Trypanosoma brucei, T. rhodesiense and T. gambiense. II. Survey of strains from East Africa and Nigeria



Transactions of the Royal Society of Tropical Medicine and Hygiene 70(5/6): 513-520



Tests were made in vivo of the sensitivity or resistance to human plasma of many strains of polymorphic trypanosomes. 5 strains of Trypanosoma gambiense from Nigeria were tested and all were highly resistant. 15 strains of T. rhodesiense (isolated from man in East Africa) were tested and they showed great variation in their degree of resistance from high resistance (5 strains) to only subresistance (2 strains). 40 strains of T. brucei (isolated from animals or tsetse flies) were tested; 20 were sensitive, 9 were doubtful (probably sensitive) and 10 were subresistant. One strain (ETAT 10, isolated from tsetse flies) was highly resistant. During this work, tests were made on 14 strains of T. brucei (isolated from animals or fly) which were recorded as having been tested on human volunteers. 6 of these strains were sensitive to human plasma and none had infected volunteers. 7 strains were subresistant, and 3 had infected volunteers. One strain was highly resistant and had infected a laboratory worker.

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Accession: 000552511

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DOI: 10.1016/0035-9203(76)90139-5


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