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Thoracic duct lymph flow and composition in conscious dogs and the influence of anaesthesia and passive limb movement

Thoracic duct lymph flow and composition in conscious dogs and the influence of anaesthesia and passive limb movement

Pflugers Archiv 371(1/2): 25-31

In dogs with a chronic thoracic duct-venous shunt, lymph flow (LF), protein concentration (LP), transported protein (LTP), albumin to globulin ratio (LAG), plasma volume (PV), intravascular protein pool (IVP) and disappearance rate of labeled albumin (k) were determined. Measurements were made in the conscious state at rest, under halothane or Nembutal anesthesia without movement and during passive movement of the hind limbs. Halothane anesthesia (6 h) reduced LF by 50% and LTP by 40%, increased LP by 18%, left LAG unchanged and produced no alteration in PV and IVP, because k was decreased by 45%. Nembutal anesthesia (6 h) reduced LF by 50%, LTP by 45%, LAG by 12%, left LP unchanged and reduced PV and IVP by 10% because k did not alter. Passive movement enhanced LF by 100%, LTP by 100% and LAG by 10%, decreased LP by 14% and did not influence PV, IVP and k. Reduced LF during halothane anesthesia may result from an overall reduction of lymph flow due to inactivation of the tissue pump and reduced capillary filtration. Reduced LF during Nembutal anesthesia arises from a reduction of muscular lymph flow due to immobilization but not from reduced capillary filtration.

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Accession: 000559718

Download citation: RISBibTeXText

PMID: 563573

DOI: 10.1007/bf00580768

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