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Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats

Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats

Journal of Nutrition 109(1): 55-62

The relationships of dietary protein to changes in hepatic aryl hydrocarbon hydroxylase activity and 7,12 dimethylbenz(a)anthracene (DMBA) carcinogenesis were studied in female Sprague-Dawley rats. Isoenergetic casein based purified diets containing 7.5, 15, or 45 percent protein equivalent were fed for 4 weeks, at which time rats were killed for enzyme assays. Aryl hydrocarbon hydroxylase, an enzyme system which metabolizes polycyclic aromatic hydrocarbons such as DMBA, showed increased activity as dietary protein increased. Evidence supports the hypothesis that increasing dietary protein may decrease the concentration of potential carcinogenic DMBA metabolites reaching the mammary gland by stimulating the hepatic metabolism of DMBA.

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Accession: 000631578

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PMID: 107295

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