Effect of cholesterol-feeding on tissue glucose uptake, insulin-degradation, serum lipids and serum lipoperoxide levels in rabbits

Tsai, A.C.; Chen, N.S.

Journal of Nutrition 109(4): 606-612


ISSN/ISBN: 0022-3166
PMID: 430263
Accession: 000638587

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The experiment was conducted to study the effect of cholesterol-feeding on tissue glucose uptake, serum insulin concentration and other metabolic parameters in rabbits. Results of this study indicate that cholesterol-feeding can increase vascular permeability to glucose, decrease serum HDL-cholesterol, and increase serum unesterified fatty acid and lipoperoxide levels. These metabolic alterations may play an important role in the pathogenesis of atherosclerosis.