Section 1
Chapter 640

Effect of falciparum malaria infection on the in vitro mitogen responses of spleen and peripheral blood lymphocytes from owl monkeys

Taylor, D.W.; Siddiqui, W.A.

American Journal of Tropical Medicine and Hygiene 27(4): 738-742


ISSN/ISBN: 0002-9637
PMID: 99058
Accession: 000639891

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In 12 Aotus trivirgatus monkeys infected at less than 25% parasitaemia with Plasmodium falciparum Vietnam-Oak Knoll strain (FVO), the response of blood lymphocytes (PBL) to mitogen stimulation was normal; but if the parasitaemia was greater than 25% the response to Concanavalin A (Con A) was depressed. A suppression of responsiveness to Con A was also seen in 8 monkeys infected with the Uganda-Palo Alto strain but at 10 to 25% parasitaemia.

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