Effect of falciparum malaria infection on the in vitro mitogen responses of spleen and peripheral blood lymphocytes from owl monkeys
Taylor, D.W.; Siddiqui, W.A.
American Journal of Tropical Medicine and Hygiene 27(4): 738-742
ISSN/ISBN: 0002-9637 PMID: 99058 Accession: 000639891
In 12 Aotus trivirgatus monkeys infected at less than 25% parasitaemia with Plasmodium falciparum Vietnam-Oak Knoll strain (FVO), the response of blood lymphocytes (PBL) to mitogen stimulation was normal; but if the parasitaemia was greater than 25% the response to Concanavalin A (Con A) was depressed. A suppression of responsiveness to Con A was also seen in 8 monkeys infected with the Uganda-Palo Alto strain but at 10 to 25% parasitaemia.