Effect of feeding sucrose or starch to rats made diabetic with streptozotocin

Hallfrisch, J.; Lazar, F.L.; Reiser, S.

Journal of Nutrition 109(11): 1909-1915


ISSN/ISBN: 0022-3166
PMID: 159348
Accession: 000640003

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A sucrose diet fed to rats augments the symptoms of diabetes in a manner to suggest that the type of carbohydrate fed to diabetics may be an important determining factor in the severity of the disease. The symptoms include higher glycosuria, polyuria, polydipsia, and a more abnormal glucose tolerance, in comparison to rats fed a starch diet. Glucose is generally higher in rats fed sucrose. Mildly diabetic rats fed sucrose show the highest perirenal fat deposits and body weights; the figures are somewhat lower for moderately diabetic rats.