Effect of host sex on passive immunity in mice infected with Nematospiroides dubius

Dobson, C.; Owen, M.E.

International Journal for Parasitology 8(5): 359-364


ISSN/ISBN: 0020-7519
PMID: 751990
DOI: 10.1016/0020-7519(78)90033-4
Accession: 000640871

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In mice given 100 Nematospiroides dubius infective larvae there was a progressive loss of worms from both Q (Quackenbush) and C3H mice with time, but the rate of loss was greater for C3H mice. Female C3H mice harboured fewer parasites than males irrespective of the duration of infection. The effects of host sex on N. dubius were not as evident in Q mice in these primary infections. C3H and Q mice became progressively immune to infection after 4 sequential doses of N. dubius larvae; females were more resistant than males. Hypothymic nu/nu CBA Balb/c mice did not show these effects. The reciprocal transfer of male and female immune mesenteric lymph node cells (IMLNC) to syngeneic male and female recipients showed that the female environment enchanced the protective qualities of both male and female IMLINC but the male environment suppressed these effects. Gonadectomized male and female recipients of male and female IMLNC had levels of infection similar to the intact female recipients. Serum from immune female mice protected both male and female recipients better than immune serum from male donors, but female mice in each treatment group were better protected than male mice. Immune serum transferred greater levels of protection than IMLNC.