Effect of pyrantel tartrate and carbadox on acquisition of the swine kidneyworm (Stephanurus dentatus) and other parasites by pigs on contaminated lots

Stewart, T.B.; Marti, O.G.; Hale, O.M.; Lomax, L.G.

American Journal of Veterinary Research 40(10): 1472-1475


ISSN/ISBN: 0002-9645
PMID: 160763
Accession: 000643206

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A combination of pyrantel tartrate (106 mg/kg body-weight) and carbadox (55 mg/kg) in ground feed was fed to 20 weaned pigs (mean weight 14.4 kg) for 42 days. Another 20 pigs were nontreated controls. The pigs were farrowed and suckled in a slat-floored farrowing house and had minimal exposure to Strongyloides ransomi until they were placed on severely contaminated dirt lots at the start of the experiment. 5 pigs from each of the 2 groups were killed on day 42. Carbadox was withheld from the feed for the 15 remaining treated pigs. All other pigs were killed when they attained market weight, 72 to 83 days later. Treated pigs killed at market weight had 44% fewer (P<0.10) Stephanurus dentatus than did control pigs. A 17% increase (P<0.01) in the weights of livers of control pigs when compared with treated market-weight pigs was associated with an increase of fibrotic hepatic tissue of control pigs. Worm infections were reduced in the treated market-weight pigs by 96% (P<0.05) for Ascaris suum, 77% (P<0.01) for Oesophagostomum spp., and 64% (P<0.01) for Strongyloides ransomi. There was some evidence for prophylaxis in market-weight pigs (P<0.10) against Metastrongylus spp., but none against Trichuris suis or Ascarops strongylina and Physocephalus sexalatus. Pigs given the pyrantel tartrate in feed until attaining market weight maintained a feed-to-gain ratio superior (7.1%) to that of nontreated pigs. [AS].