+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effect of vitamin D on growth in experimental uremia



Effect of vitamin D on growth in experimental uremia



American Journal of Clinical Nutrition 31(10): 1927-1931



Acceleration of growth of uremic children after administration of vitamin D has been demonstrated by various authors. This has been attributed to healing of skeletal lesions. Clinical observations suggest that vitamin D has also an effect on food intake perhaps associated with improvement of vitality. This could be confirmed in an experimental study in which uremic rats (subtotal nephrectomy) with and without vitamin D supplementation were compared with sham-operated pair-fed control rats with and without vitamin D supplementation. In uremic animals supplemented with vitamin D, weight gain and growth were significantly greater than in uremic animals on the control diet. Both with and without vitamin D supplements, weight gain and growth rate were greater in sham-operated pair-fed control than in the corresponding uremic animals. Histological abnormalities in the growth zone of uremic rats were markedly reduced by vitamin D. Since food intake was greater in vitamin D-treated uremic animals than in nonvitamin D-treated uremic animals, the increase in growth rate under vitamin D cannot be attributed exclusively to the skeletal effects of vitamin D. This study demonstrates important extraskeletal actions of vitamin D which may be associated with or causally related to the improvement of growth.

(PDF emailed within 1 workday: $29.90)

Accession: 000645589

Download citation: RISBibTeXText

PMID: 707349


Related references

Effect of vitamin d 3 and 1 25 di hydroxy vitamin d 3 on growth in experimental uremia. Pediatric Research 14(12): 1418, 1980

Differential effects of hypophagia and vitamin d vd deficiency on growth in experimental uremia. Pediatric Research 21(4 PART 2): 470A, 1987

Relative effects of oral and parenteral vitamin d supplementation on growth in experimental uremia. Kidney International 33(1): 334, 1988

Differential effects on growth and mortality with vitamin d analogue supplementation in experimental uremia. Kidney International 37(1): 463, 1990

Hypoglycemic effects of insulin-like growth factor-1 in experimental uremia: can concomitant growth hormone administration prevent this effect?. Hormone Research 51(4): 193-200, 1999

Treatment of uremic osteopathy. Effects of vitamin D metabolites and vitamin D analogs in chronic uremia and experimental renal insufficiency. Mmw, Munchener Medizinische Wochenschrift 116(37): 1573-1578, 1974

Effect of parathyroid hormone calcitonin and growth hormone on cyclic amp content of growth cartilage in experimental uremia. European Journal of Clinical Investigation 12(4): 337-344, 1982

Effect of parathyroid hormone calcitonin and growth hormone on growth cartilage in experimental uremia. Kidney International 20(1): 155, 1981

25-OH-Vitamin D in experimental and clinical uremia. Calcified Tissue Research 22 Suppl: 430-433, 1977

Vitamin D metabolism in experimental uremia. Israel Journal of Medical Sciences 7(3): 536-537, 1971

The nature of vitamin D resistance in experimental uremia. Archives of Internal Medicine 126(5): 891-895, 1970

Intestinal absorption of vitamin A in experimental uremia. Acta Vitaminologica et Enzymologica 6(1): 41-45, 1984

Osteopathy in experimental uremia. 1. Vitamin D-resistance. Klin. Wochenschr, 49: 113-115, 1971

Abnormal expression and regulation of vitamin D receptor in experimental uremia. Nephron 73(4): 619-628, 1996

1,25(OH)2 vitamin D3 inhibits parathyroid cell proliferation in experimental uremia. Kidney International 35(4): 1049-1056, 1989