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Evidence of riboflavin depletion in breast-fed newborns and its further acceleration during treatment of hyperbilirubinemia by phototherapy


, : Evidence of riboflavin depletion in breast-fed newborns and its further acceleration during treatment of hyperbilirubinemia by phototherapy. Acta Paediatrica Scandinavica 68(4): 567-570

Phototherapy in the treatment of newborns with hyperbilirubinemia, resulting in degradation of bilirubin, also appears to have other photodynamic effects on metabolism. FAD saturation of erythrocyte glutathione reductase which should reflect riboflavine nutritional status in 28 healthy newborns, was studied. Newborns (37) with hyperbilirubinemia prior to the start of and during phototherapy were also studied. Healthy newborns on human milk feeding, relatively poor in riboflavine, have evidence of a transient riboflavine depletion soon after birth. This effect is made more pronounced by phototherapy and partially prevented by parenteral or oral administration of moderate amounts of riboflavine.

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Accession: 000656024

PMID: 463539

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Related references

Hodr, R.; Knobloch, E.; Vondrácek, J.; Procházková, E.; Houdková, V., 1981: Levels of riboflavin in the blood of normal newborns and during phototherapy for hyperbilirubinemia. Ceskoslovenska Pediatrie 36(2): 62-64

Hodr, R., 1977: Acceleration of the therapeutic effect of light using riboflavin during phototherapy of neonatal hyperbilirubinemia. Ceskoslovenska Pediatrie 32(4): 224-225

Misra, P.K.; Govil, Y.C., 1987: Role of riboflavin with phototherapy in the treatment of neonatal hyperbilirubinemia. Newborn infants with hyperbilirubinaemia were given continuous phototherapy alone (18) or with riboflavin sodium phosphate 1.5 mg/kg (22). The percentage decrease in plasma bilirubin after 1, 2 and 3 days of phototherapy was 7.55, 14.66 and 10.99%...

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Karadag, A.; Demirin, H.; Dogan, D.Gumus.; Aslan, M.; Tatli, M.Mansur., 2010: Phototherapy, hyperbilirubinemia and genotoxicity in newborns. Mutation Research 697(1-2): 68; Author Reply 69-68; Author Reply 69

Hovi L.; Hekali R.; Siimes M.A., 1979: Evidence of riboflavine depletion in breast fed new borns and its further acceleration during treatment of hyper bilirubinemia by photo therapy. Phototherapy in the treatment of newborns with hyperbilirubinemia, resulting in degradation of bilirubin, also appears to have other photodynamic effects on metabolism. FAD saturation of erythrocyte glutathione reductase which should reflect ribof...

Gosal, N.M., 1977: Phototherapy and inductors of enzymes in hyperbilirubinemia in newborns. Pediatriia: 75-78