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Histamine and insulin dose-response studies of gastric secretion in Indian control subjects and patients with duodenal ulcer in the Ganges delta



Histamine and insulin dose-response studies of gastric secretion in Indian control subjects and patients with duodenal ulcer in the Ganges delta



Gut 19(10): 878-885



The gastric secretory responses to various doses of histamine and insulin were studied in 11 control and 12 duodenal ulcer subjects belonging to the Ganges delta of India where there is a high incidence of duodenal ulcer disease. A dose of 0.04 mg/kg body weight of histamine acid phosphate was sufficient to produce peak gastric acid output both in the control and duodenal ulcer subjects. A dose as low as 0.025 U insulin/kg body weight was enough to produce peak rates of gastric acid output in duodenal ulcer subjects, whereas in the controls a minimum dose of 0.05 U insulin/kg body weight was sufficient. A greater proportion of the duodenal ulcer patients also showed a peak acid secretory response in the 1st h after administration of insulin. Increasing doses of insulin in this population did not produce lower levels of blood glucose but did produce increasingly high acid output as subjects do in the West. K values derived from the i.v. glucose tolerance test showed that 75% of duodenal ulcer patients and 54% of the controls had variable degrees of intolerance to glucose. Gastric acid secretion in response to a bolus of 50 ml 50% i.v. glucose was also studied in a separate group of 16 duodenal ulcer and 13 control subjects. A sharp rise in the volume, titratable acidity, and total acid output was observed in the early part of the 4th h in the control and duodenal ulcer subjects. In a separate group of controls a bolus of i.v. hypertonic saline produced no such increase in gastric acid secretion.

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Accession: 000673231

Download citation: RISBibTeXText

PMID: 710959

DOI: 10.1136/gut.19.10.878



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