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Chapter 677

Immune mechanisms against canine distemper. III. Role of complement lysis in the immunity and persistent infection of canine distemper virus

Ho, C.K.; Babiuk, L.A.

Immunology 39(2): 231-237

1980


ISSN/ISBN: 0019-2805
PMID: 7380468
Accession: 000676313

Antibody-mediated complement lysis of Vero cells and canine macrophages infected with canine distemper virus was demonstrated in an in vitro 51Cr release assay. This cytolytic activity was found to be highly efficient and was optimal under conditions which favoured the capping of redistribution of surface viral antigens. A prozone was observed in the presence of high antibody concentration and could not be eliminated by repeated washings.

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