+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Plasmodium gallinaceum: transmission-blocking immunity in chickens. II. The effect of antigamete antibodies in vitro and in vivo and their elaboration during infection



Plasmodium gallinaceum: transmission-blocking immunity in chickens. II. The effect of antigamete antibodies in vitro and in vivo and their elaboration during infection



Experimental Parasitology 47(2): 194-208



Heat-inactivated serum from chickens with transmission-blocking immunity to Plasmodium gallinaceum prevented the in vitro development of ookinetes from gametocytes of P. gallinaceum only when present during the period between the initiation of gametogenesis and the release of the microgametes. When added after this time immune serum failed to suppress ookinete development. Immune serum did not prevent the formation of gametes from gametocytes. These results are interpreted to indicate that immune serum contains factors which prevent fertilization of the malarial gametes but which do not affect the development of the zygote once fertilization has taken place. Two distinct reactions of malarial gametes with serum from chickens with transmission-suppressing immunity are described-the gamete-agglutination (AG) reaction and the microgamete surface-fixation (SF) reaction. Both reactions were associated with the immunoglobulin fraction of immune serum. The presence of SF antibodies during a blood infection correlated closely with effective transmission-blocking immunity in vivo; AG antibodies, on the other hand, were present in various circumstances in the absence of transmission-blocking immunity. AG and SF antibodies occurred not only in birds immunized with P. gallinaceum-gamete preparations but also during or following infections in unimmunized birds; SF antibodies appeared only following the peak of asexual infection in unimmunized birds and were of low titre. In immunized birds blood infections following live challenge invariably boosted low levels of SF antibodies. [AS].

(PDF emailed within 0-6 h: $19.90)

Accession: 000719787

Download citation: RISBibTeXText

PMID: 556175

DOI: 10.1016/0014-4894(79)90073-0


Related references

Plasmodium gallinaceum: transmission-blocking immunity in chickens. 1. Comparative immunogenicity of gametocyte- and gamete-containing preparations. Experimental Parasitology 47(2): 185-193, 1979

Phase separation in Triton X-114 of antigens of transmission blocking immunity in Plasmodium gallinaceum. Molecular and Biochemical Parasitology, 173: 343-358, 1985

Step procedure for separation of 1 of the target antigens of transmission blocking immunity in plasmodium gallinaceum. Journal Of Cellular Biochemistry Supplementt A: 20, 1983

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro. Vaccine 27(38): 5187-5194, 2009

A surface protein expressed during the transformation of zygotes of Plasmodium gallinaceum is a target of transmission-blocking antibodies. Infection and Immunity 45(3): 775-777, 1984

In vivo transmission blocking activities of artesunate on the avian malaria parasite Plasmodium gallinaceum. Veterinary Parasitology 197(3-4): 447-454, 2014

Immunization studies with an antigenic target of transmission blocking immunity purified from plasmodium gallinaceum zygotes with mono clonal antibody. Federation Proceedings 41(3): ABSTRACT 1249, 1982

The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro. Vaccine 33(3): 437-445, 2015

The effect of Plasmodium gallinaceum infection upon elution of chromium-51 from erthrocytes of chickens. Dissertation Abstracts, 29B 1883-1884, 1968

The effect of Plasmodium gallinaceum on a challenge infection with Ascaridia galli in chickens. Veterinary Parasitology 105(1): 11-19, 2002

Antisporozoite antibodies with protective and nonprotective activities: in vitro and in vivo correlations using Plasmodium gallinaceum, an avian model. Journal of Eukaryotic Microbiology 42(6): 705-708, 1995

Reproduction-inhibiting and parasiticidal effects on Plasmodium gallinaceum and Plasmodium lophurae during initial infection and homologous superinfection in chickens. Jour Infect Dis 86(3): 275-294, 1950

Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230. Parasitology 119: 425-433, 1999

Monoclonal antibody against the Plasmodium falciparum chitinase, PfCHT1, recognizes a malaria transmission-blocking epitope in Plasmodium gallinaceum ookinetes unrelated to the chitinase PgCHT1. Infection and Immunity 70(3): 1581-1590, 2002

Transmission blocking immunity in Plasmodium vivax malaria: antibodies raised against a peptide block parasite development in the mosquito vector. Journal of Experimental Medicine 181(1): 357-362, 1995