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Production of iron deficiency anemia and the effect of iron supplementation on the anemic status in rats



Production of iron deficiency anemia and the effect of iron supplementation on the anemic status in rats



Japanese Journal of Nutrition 37(3): 147-154



Production of Fe-deficiency anemia in rats fed an Fe-poor diet and the effect of Fe supplementation on anemia were investigated. Male Wistar strain rats weighing about 150 g were given an Fe-poor diet for about 1 mo. Hb levels, hematocrit [Ht] and red blood cells [RBC] were compared to those in control animals and Fe content in the liver, spleen and bone marrow in rats with Fe-deficiency anemia were tested. Hb, Ht and RBC decreased markedly compared to those of the control group, registering Hb 8.0 g/dl, Ht 29.8% and RBC 539 .times. 104/mm3 at the end of the experiment. The Fe content of those tissues decreased and the activities of .delta.-aminolevulinic acid synthetase in the bone marrow decreased compared to those of control animals. Fe-deficient animals were fed 2 diets (diet A, 20% casein + 4.10 mg% Fe; and diet B, 10% casein + 1.80 mg% Fe) for 10 days. In both groups the values of Hb, Ht and RBC at the 10th day increased rapidly but the Fe content of each organ did not show a rapid increase.

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Accession: 000726142

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