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Prolonged intravenous infusion of labelled iodocompounds in the rat: [125I]thyroxine and [125I]tri-iodothyronine metabolism and extrathyroidal conversion of thyroxine to tri-iodothyronine



Prolonged intravenous infusion of labelled iodocompounds in the rat: [125I]thyroxine and [125I]tri-iodothyronine metabolism and extrathyroidal conversion of thyroxine to tri-iodothyronine



Journal of Endocrinology 82(2): 235-241



Male Wistar rats were given a diet high in iodine. For 2 days before and during the infusion of thyroxine (T4) or triiodothyronine (T3) labelled with 125I, 6 and 3 mu Ci daily for 8 to 15 and 6 to 9 days, respectively, they were given potassium iodide 10 mg/litre drinking water. Significant amounts of labelled T3 were present in all tissues studied after infusion of 4, confirming that conversion of T4 to T3 occurs in tissues other than the thyroid.

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Accession: 000727119

Download citation: RISBibTeXText

PMID: 490079

DOI: 10.1677/joe.0.0820235



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